THEORETICAL CONSIDERATIONS ON GERMLINE MOSAICISM IN DUCHENNE MUSCULAR-DYSTROPHY

被引：28

作者：

GRIMM, T

MULLER, B

MULLER, CR

JANKA, M

机构：

[1] Institut für Humangenetik, Universität Würzburg, D-8700 Würzburg

来源：

JOURNAL OF MEDICAL GENETICS | 1990年 / 27卷 / 11期

关键词：

D O I：

10.1136/jmg.27.11.683

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A newly formulated mutation selection equilibrium for lethal X linked recessive traits such as Duchenne muscular dystrophy is presented, which allows for both male and female germline mosaicism. Estimates of the additional parameters used are given, thus allowing the incorporation of germline mosaicism into the calculation of genetic risks.

引用

页码：683 / 687

页数：5

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