T-CELL RECEPTOR GENE REARRANGEMENTS AND THE DIAGNOSIS OF HUMAN T-CELL NEOPLASMS

被引：14

作者：

COSSMAN, J ^{[1
]}

UPPENKAMP, M ^{[1
]}

ANDRADE, R ^{[1
]}

MEDEIROS, LJ ^{[1
]}

机构：

[1] NCI, PATHOL LAB, BETHESDA, MD 20892 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 1990年 / 10卷 / 03期

关键词：

D O I：

10.1016/1040-8428(90)90035-Q

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rearranging antigen receptor genes of lymphoid cells serve as unique clonal markers of lymphoid neoplasms. Gene rearrangement analysis is a highly sensitive and reproducible tool which is useful in the diagnosis and classification of malignant lymphoma/leukemia. Although clonality can often be determined among B cell neoplasms by virtue of immunoglobulin isotype analysis, no such phenotypic marker of clonality exists for T cells. Therefore, clonality of T lymphoproliferative processes is most readily determined by rearrangement analysis of the T cell antigen receptor genes. The alpha, beta, gamma, and delta genes of the T cell receptor gene family encode heterodimeric surface antigen receptors and undergo rearrangement early in T cell differentiation. Identification of rearrangement of T cell antigen receptor genes provides valuable diagnostic information concerning cellular lineage, clonality and classification of T cell neoplasms. This molecular approach is applicable to the diagnosis of occult disease, relapse, and resolution of diagnostic dilemmas in any type of tissue sample including fluids and needle aspirations. © 1990.

引用

页码：267 / 281

页数：15

共 226 条

[1] PURIFICATION AND NH2-TERMINAL AMINO-ACID SEQUENCING OF THE BETA-SUBUNIT OF A HUMAN T-CELL ANTIGEN RECEPTOR [J].