THE INNERVATION OF THE HUMAN PROSTATE-GLAND - THE CHANGES ASSOCIATED WITH BENIGN ENLARGEMENT

被引:63
作者
CHAPPLE, CR
CROWE, R
GILPIN, SA
GOSLING, J
BURNSTOCK, G
机构
[1] UNIV LONDON UNIV COLL, DEPT ANAT & DEV BIOL, LONDON WC1E 6BT, ENGLAND
[2] UNIV MANCHESTER, DEPT ANAT, MANCHESTER M13 9PL, LANCS, ENGLAND
关键词
PROSTATE; BLADDER; NEUROPHARMACOLOGY;
D O I
10.1016/S0022-5347(17)38203-4
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Different regions of the prostate gland, namely prostatic capsule, peripheral prostate and central prostate (subdivided into proximal (near the bladder neck), distal (near the verumontanum) and midway between these areas) were obtained from 32 obstructed (stable obstructed, n = 8; unstable obstructed, n = 13; acute retention, n = 11) and five control patients. The innervation of these tissues was studied both histochemically to localise acetylcholinesterase activity and immunohistochemically for dopamine-beta-hydroxylase, 5-hydroxytryptamine, vasoactive intestinal polypeptide, neuropeptide Y, leu- and met-enkephalin, calcitonin gene-related peptide, substance P and somatostatin. In control patients the greatest density of nerves was found in the proximal central prostate, followed by the anterior capsule and distal central prostate, with the least density in the peripheral prostate. The greatest density of nerves were acetycholinesterase positive and immunoreactive to neuropeptide Y followed (in decreasing order) by nerves immunoreactive to: vasoactive intestinal polypeptide and dopamine beta-hydroxylase; leu-enkephalin and 5-hydroxytryptamine; calcitonin gene-related peptide; met-enkephalin; substance P; somatostatin. In addition a group of periacinar 5-hydroxytryptamine-immunoreactive cells and ganglia containing acetylcholinesterase, dopamine beta-hydroxylase and all of the peptides studied except somatostatin were identified. In the prostate gland from obstructed patients there was a significant reduction in the density of acetylcholinesterase-positive nerves (p < 0.001) when compared with the controls. A similar trend was found for dopamine beta-hydroxylase, 5-hydroxytryptamine and all of the putative neuropeptides in most areas of the prostate, the most notable exceptions being in the peripheral prostate, with an increase in dopamine beta-hydroxylase- and leu-enkephalin-immunoreactive nerves in all three groups of obstructed patients and an increase in vasoactive intestinal polypeptide- and calcitonin gene-related peptide-immunoreactive nerves in those presenting in urinary retention. The functional significance of these findings is discussed.
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收藏
页码:1637 / 1644
页数:8
相关论文
共 50 条
[1]   DETRUSOR INSTABILITY AND BLADDER OUTLET OBSTRUCTION [J].
ABRAMS, P .
NEUROUROLOGY AND URODYNAMICS, 1985, 4 (04) :317-328
[2]  
ABRAMS P, 1988, SCAND J UROL NEPHROL, P5
[3]   NEUROPEPTIDE-Y IN THE HUMAN MALE GENITAL-TRACT [J].
ADRIAN, TE ;
GU, J ;
ALLEN, JM ;
TATEMOTO, K ;
POLAK, JM ;
BLOOM, SR .
LIFE SCIENCES, 1984, 35 (26) :2643-2648
[4]  
ALM P, 1980, CELL TISSUE RES, V205, P337
[5]   LIGHT MICROSCOPIC STEREOLOGICAL ANALYSIS OF THE NORMAL HUMAN-PROSTATE AND OF BENIGN PROSTATIC HYPERPLASIA [J].
BARTSCH, G ;
MULLER, HR ;
OBERHOLZER, M ;
ROHR, HP .
JOURNAL OF UROLOGY, 1979, 122 (04) :487-491
[6]   ADRENERGIC INNERVATION OF HUMAN TESTIS EPIDIDYMIS DUCTUS DEFERENS AND PROSTATE - A FLUORESCENCE MICROSCOPIC AND FLUORIMETRIC STUDY [J].
BAUMGARTEN, HG ;
FALCK, B ;
HOLSTEIN, AF ;
OWMAN, C ;
OWMAN, T .
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE, 1968, 90 (01) :81-+
[7]  
BRUSCHINI H, 1978, INVEST UROL, V15, P288
[8]   ADRENERGIC AND CHOLINERGIC RECEPTORS IN HUMAN PROSTATE, PROSTATIC CAPSULE AND BLADDER NECK [J].
CAINE, M ;
RAZ, S ;
ZEIGLER, M .
BRITISH JOURNAL OF UROLOGY, 1975, 47 (02) :193-202
[9]  
CAINE M, 1986, FASEB J, V45, P2604
[10]  
CAINE M, 1986, J UROLOGY, V136, P1