INTERACTIONS OF MOCLOBEMIDE WITH CONCOMITANTLY ADMINISTERED MEDICATION - EVIDENCE FROM PHARMACOLOGICAL AND CLINICAL-STUDIES

被引：54

作者：

AMREIN, R ^{[1
]}

GUNTERT, TW ^{[1
]}

DINGEMANSE, J ^{[1
]}

LORSCHEID, T ^{[1
]}

STABL, M ^{[1
]}

SCHMIDBURGK, W ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD, DEPT CLIN RES, CH-4002 BASEL, SWITZERLAND

来源：

PSYCHOPHARMACOLOGY | 1992年 / 106卷

关键词：

MOCLOBEMIDE; INTERACTIONS; PHARMACOKINETICS; PHARMACOLOGICAL DATA;

D O I：

10.1007/BF02246229

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interactions may occur on pharmacological or pharmacokinetic grounds. Both types of interactions are discussed in relationship with the pharmacological and pharmacokinetic data of moclobemide, a reversible MAO-inhibitor. A variety of interaction studies either designed more specifically as kinetic or as dynamic studies have been performed with moclobemide. The results of these studies are presented. In view of these results as well as in view of data stemming from clinical trials it can be concluded that apart from interactions with cimetidine and pethidine, moclobemide has been shown to be devoid of relevant interactions.

引用

页码：S24 / S31

页数：8

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