CD4+ LYMPHOCYTE DEPLETION IN HIV-INFECTED PATIENTS IS ASSOCIATED WITH GP120-IMMUNOGLOBULIN-COMPLEMENT ATTACHMENT TO CD4+ CELLS

被引：29

作者：

DANIEL, V ^{[1
]}

SUSAL, C ^{[1
]}

PRODEUS, AP ^{[1
]}

WEIMER, R ^{[1
]}

ZIMMERMANN, R ^{[1
]}

HUTHKUHNE, A ^{[1
]}

OPELZ, G ^{[1
]}

机构：

[1] REHABIL HOSP & HEMOPHILIA CTR,HEIDELBERG,GERMANY

来源：

VOX SANGUINIS | 1993年 / 64卷 / 01期

关键词：

D O I：

10.1111/j.1423-0410.1993.tb02511.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanism of CD4+ lymphocyte depletion, which is the main immunological feature in HIV-infected patients, is unclear. We investigated whether gp120-immunoglobulin-complement complexes on the surface of CD4+ cells might be involved in the elimination of CD4+ lymphocytes. The results obtained in 63 HIV-infected patients show that gp120 is attached to a variable degree to CD4+ cells. Importantly, the percentage of CD4+gp120+ lymphocytes is inversely associated with CD4+ lymphocyte counts in the peripheral blood (p = 0.0004). CD4+gp120+ blood lymphocytes bind IgM (p = 0.0027) and IgG antibodies (p = 0. 0001) and complement (p = 0.0005). These results suggest that immune complex-mediated cell elimination is an important mechanism of CD4+ cell depletion in patients with AIDS.

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页码：31 / 36

页数：6

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