DECREASED BEHAVIORAL-EFFECTS OF DAILY INTRACEREBROVENTRICULAR BOMBESIN

被引：11

作者：

CORWIN, RL

CORP, ES

GIBBS, J

SMITH, GP

机构：

[1] NEW YORK HOSP, CORNELL MED CTR, EW BOURNE BEHAV RES LAB, WHITE PLAINS, NY 10605 USA

[2] CORNELL UNIV, MED CTR, COLL MED, DEPT PSYCHIAT, NEW YORK, NY 10021 USA

来源：

PEPTIDES | 1992年 / 13卷 / 06期

关键词：

TOLERANCE; GROOMING; INGESTION; CENTRAL EFFECTS OF PEPTIDES; CENTRAL EFFECTS OF BOMBESIN; FOOD INTAKE; FEEDING BEHAVIOR;

D O I：

10.1016/0196-9781(92)90031-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.

引用

页码：1215 / 1218

页数：4

共 29 条

[1] ISOLATION AND STRUCTURE OF BOMBESIN AND ALYTESIN, 2 ANALOGOUS ACTIVE PEPTIDES FROM SKIN OF EUROPEAN AMPHIBIANS BOMBINA AND ALYTES [J].