LOCALIZATION OF 4 ANTIGENIC SITES INVOLVED IN VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS PROTECTION

被引:24
作者
AGAPOV, EV [1 ]
RAZUMOV, IA [1 ]
FROLOV, IV [1 ]
KOLYKHALOV, AA [1 ]
NETESOV, SV [1 ]
LOKTEV, VB [1 ]
机构
[1] STATE RES CTR VIROL & BIOTECHNOL VECTOR,INST MOLEC BIOL,KOLTSOV 633159,RUSSIA
关键词
D O I
10.1007/BF01309462
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Stable neutralization and protection escape variants of a virulent strain (Trinidad Donkey) of the VEE virus were selected by monoclonal antibodies (MAbs). Determination of nucleotide sequences of nine variants revealed a clustering of single mutations in four regions of the El and E2 glycoproteins. Involvement of amino acid residues 206 (site El-l), 57 and 59 (site E2-2), 180, 182, 213, 214 and 216 (site E2-6) and 232 (site E2-3) in protective epitopes was demonstrated.
引用
收藏
页码:173 / 181
页数:9
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