DISEASE PROCESSES IN EPITHELIA - THE ROLE OF THE ACTIN CYTOSKELETON AND ALTERED SURFACE-MEMBRANE POLARITY

被引：46

作者：

LEISER, J

MOLITORIS, BA

机构：

[1] INDIANA UNIV,SCH MED,MED CTR,DEPT MED,INDIANAPOLIS,IN 46202

[2] UNIV COLORADO,SCH MED,VET AFFAIRS MED CTR,DEPT MED,DENVER,CO

[3] UNIV COLORADO,SCH MED,DEPT CELLULAR & STRUCT BIOL,DENVER,CO

[4] UNIV COLORADO,SCH MED,CHILDRENS HOSP,DEPT PEDIAT,DENVER,CO

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1225卷 / 01期

关键词：

EPITHELIAL POLARITY; CYTOSKELETON; ISCHEMIA; PROXIMAL TUBULE; MICROVILLOUS INCLUSION DISEASE; POLYCYSTIC KIDNEY DISEASE;

D O I：

10.1016/0925-4439(93)90115-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The establisment and maintenance of cell polarity is essential for normal epithelial function. Disruption of the underlying processes, either as a primary inborn defect or as a secondary result of other pathologic processes, can lead to loss of epithelial polarity and further cellular and organ-level dysfunction. Continued elucidation of the processes involved may prove fruitful both in the understanding of basic cell biology and in the understanding and treatment of a variety of disease states. © 1993.

引用

页码：1 / 13

页数：13

共 121 条

[1] ROLE OF MICROTUBULES IN POLARIZED DELIVERY OF APICAL MEMBRANE-PROTEINS TO THE BRUSH-BORDER OF THE INTESTINAL EPITHELIUM [J].