ROLE OF NEUROTROPHINS IN CHOLINERGIC-NEURON FUNCTION IN THE ADULT AND AGED CNS

被引：122

作者：

RYLETT, RJ ^{[1
]}

WILLIAMS, LR ^{[1
]}

机构：

[1] AMGEN INC, THOUSAND OAKS, CA 91320 USA

来源：

TRENDS IN NEUROSCIENCES | 1994年 / 17卷 / 11期

关键词：

D O I：

10.1016/0166-2236(94)90138-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cholinergic neurones in the CNS undergo complex changes during normal aging. In recent years, considerable attention has focussed on the neurotrophins and, in particular, nerve growth factor, as potential maintenance factors for cholinergic-neurone function, and as therapeutic agents for use in a variety of neurodegenerative disorders including Alzheimer's disease. While brain cholinergic neurones from the neonate to the aged respond to nerve growth factor with enhanced expression of transmitter phenotype, there appears to be an age-related, region-specific decline in responsiveness. This age-related decrement in neurotrophin action might play a role in dysfunction of cholinergic neurones, and cognitive loss, and could limit the use of these factors as therapeutic agents.

引用

页码：486 / 490

页数：5

共 65 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].