PROTEIN PHOSPHATASE INHIBITORY ACTIVITY IN EXTRACTS OF CULTURED BLUE-GREEN-ALGAE (CYANOPHYTA)

被引:21
作者
HONKANEN, RE
CAPLAN, FR
BAKER, KK
BALDWIN, CL
BOBZIN, SC
BOLIS, CM
CABRERA, GM
JOHNSON, LA
JUNG, JH
LARSEN, LK
LEVINE, IA
MOORE, RE
NELSON, CS
PATTERSON, GML
TSCHAPPAT, KD
TUANG, GD
BOYNTON, AL
ARMENT, AR
AN, J
CARMICHAEL, WW
RODLAND, KD
MAGUN, BE
LEWIN, RA
机构
[1] UNIV HAWAII MANOA,DEPT CHEM,HONOLULU,HI 96822
[2] PACIFIC NW RES FDN,DIV CELL & MOLEC BIOL,SEATTLE,WA 98122
[3] WRIGHT STATE UNIV,DEPT BIOL SCI,DAYTON,OH 45435
[4] OREGON HLTH SCI UNIV,DEPT CELL BIOL & ANAT,PORTLAND,OR 97201
[5] UNIV CALIF SAN DIEGO,SCRIPPS INST OCEANOG,LA JOLLA,CA 92093
关键词
CYANOBACTERIA; MICROALGAE; MICROCYSTIN; NATURAL PRODUCTS; NODULARIN; OKADAIC ACID; PROTEIN PHOSPHATASE INHIBITORS;
D O I
10.1111/j.0022-3646.1995.00478.x
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A large-scale screening program was initiated to evaluate laboratory-cultured blue-green algae (cyanobacteria) as a source of novel compounds with inhibitory activity against certain serine/threonine protein phosphatases. Over 1600 extracts, representing 816 cyanophyte strains with broad habitat and taxonomic diversity were screened. Inhibitors were identified in extracts produced from all orders tested except Chamaesiphonales, and the family Stigonemataceae was found to contain proportionally more inhibitors as compared to the total screen.
引用
收藏
页码:478 / 486
页数:9
相关论文
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