ENHANCEMENT OF HUMAN LYMPHOCYTE-T FUNCTION BY PROTHYMOSIN-ALPHA - INCREASED PRODUCTION OF INTERLEUKIN-2 AND EXPRESSION OF INTERLEUKIN-2 RECEPTORS IN NORMAL HUMAN PERIPHERAL-BLOOD LYMPHOCYTES-T

被引：24

作者：

BAXEVANIS, CN ^{[1
]}

FRILLINGOS, S ^{[1
]}

SEFERIADIS, K ^{[1
]}

RECLOS, GJ ^{[1
]}

ARSENIS, P ^{[1
]}

KATSIYIANNIS, A ^{[1
]}

ANASTASOPOULOS, E ^{[1
]}

TSOLAS, O ^{[1
]}

PAPAMICHAIL, M ^{[1
]}

机构：

[1] UNIV IOANNINA,SCH MED,BIOL CHEM LAB,GR-45110 IOANNINA,GREECE

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1990年 / 12卷 / 04期

关键词：

D O I：

10.3109/08923979009019679

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (Prot-alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with Prot-alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. Prot-alpha by itself did not exert any IL-2 activity. Finally, Prot-alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of Prot-alpha in cellular immune systems.

引用

页码：595 / 617

页数：23

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