INHIBITION OF CYTOMEGALO-VIRUS LATE ANTIGENS BY PHOSPHONOFORMATE

被引：52

作者：

WAHREN, B ^{[1
]}

OBERG, B ^{[1
]}

机构：

[1] ASTRA LAKEMEDEL AB,RES & DEV LABS,S-15185 SODERTALJE,SWEDEN

来源：

INTERVIROLOGY | 1979年 / 12卷 / 06期

关键词：

D O I：

10.1159/000149093

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Phosphonoformate (PFA) at a concentration of 500 μM and higher completely inhibited the replication of cytomegalovirus (CMV) in cell culture. 50% inhibition was obtained at a concentration of 100 μM PFA. Early nuclear CMV antigens appeared uninhibited, but the formation of nuclear inclusion bodies, late cytoplasmic antigens, Fc- receptors and CPE were all inhibited by PFA. No visible cell toxicity was noted at the PFA concentrations and exposure times used.

引用

页码：335 / 339

页数：5

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