POSSIBLE ACCELERATED STRIATAL AGING INDUCED BY FE-56 HEAVY-PARTICLE IRRADIATION - IMPLICATIONS FOR MANNED SPACE-FLIGHTS

被引:111
作者
JOSEPH, JA [1 ]
HUNT, WA [1 ]
RABIN, BM [1 ]
DALTON, TK [1 ]
机构
[1] ARMED FORCES RADIOBIOL RES INST, DEPT BEHAV SCI, BETHESDA, MD 20889 USA
关键词
D O I
10.2307/3578484
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The present experiments were carried out to determine the effects of energy deposition from energetic iron (56Fe particles, an important component of cosmic rays) on motor behavioral performance and to determine if the observed deficits were caused by alterations in the neostriatum (an important motor control area). Neostriatal function was assessed with two correlated parameters, i.e., motor behavioral performance (wire suspension task), and oxotremorine-enhanced K+-evoked release of dopamine from perifused striatal slices. Rats were exposed to one of several doses of 56Fe-particle irradiation (0.10-1.0 Gy) and tested on a wire suspension task at 3-180 days postirradiation. Results indicated that profound decrements occurred in both of these indices. The effects on K+-evoked release of dopamine were evident for as long as 180 days after irradiation, and a subsequent experiment indicated that these effects appeared as early as 12 h postirradiation. Since similar findings have been observed in aged rats, the results are discussed in terms of these particles producing a possible accelerated striatal aging effect.
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页码:88 / 93
页数:6
相关论文
共 49 条
[1]  
ADELMAN RC, 1979, FED PROC, V38, P1968
[2]  
AINSWORTH EJ, 1976, BIOL ENV EFFECTS LOW, V2, P77
[3]   ACCELERATED AGEING - A LONG TERM EFFECT OF EXPOSURE TO IONIZING RADIATIONS [J].
ALEXANDER, P .
GERONTOLOGIA, 1957, 1 (03) :174-193
[4]  
BARNES DJ, 1966, TR66106 USAF SCH AER
[5]  
BARNES DJ, 1968, TR6881 USAF SCH AER
[6]   THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].
BARTUS, RT ;
DEAN, RL ;
BEER, B ;
LIPPA, AS .
SCIENCE, 1982, 217 (4558) :408-417
[7]  
BERNHEIMER H, 1973, J NEUROL SCI, V20, P415, DOI 10.1016/0022-510X(73)90175-5
[8]   EFFECTS OF BREMSSTRAHLUNG AND ELECTRON-RADIATION ON RAT MOTOR-PERFORMANCE [J].
BOGO, V .
RADIATION RESEARCH, 1984, 100 (02) :313-320
[9]   SENSORIMOTOR DEFICITS PRODUCED BY PHENYTOIN AND CHLORPROMAZINE IN UNANESTHETIZED CATS [J].
CARP, JS ;
ANDERSON, RJ .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1979, 10 (04) :513-520
[10]  
Cools AR., 1984, BASAL GANGLIA, P513