AMINO-ACID-CONCENTRATIONS IN CEREBROSPINAL-FLUID AND PLASMA IN ALZHEIMERS-DISEASE AND HEALTHY CONTROL SUBJECTS

被引:73
作者
BASUN, H
FORSSELL, LG
ALMKVIST, O
COWBURN, RF
EKLOF, R
WINBLAD, B
WETTERBERG, L
机构
[1] HUDDINGE HOSP,DEPT GERIATR MED,S-14186 HUDDINGE,SWEDEN
[2] HUDDINGE HOSP,DEPT CLIN CHEM,S-14186 HUDDINGE,SWEDEN
[3] STOCKHOLM GERONTOL RES CTR,STOCKHOLM,SWEDEN
关键词
DEMENTIA OF ALZHEIMER TYPE; AMINO ACIDS; CSF; PLASMA;
D O I
10.1007/BF02252924
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cerebrospinal fluid (CSF) and plasma levels of 18 amino acids were studied in 22 subjects with dementia of the Alzheimer type (DAT) and in 11 healthy volunteers with no clinical or family history of dementia. Significant decreases of plasma taurine and glutamate were seen in the DAT cases compared with the controls. The CSF concentrations of glycine, leucine and valine were also significantly reduced in the DAT cases. Furthermore, in the DAT cases significant decreases were observed in the ratio between CSF and plasma (CSF/P) levels for alanine, glutamine, glycine, phenylalanine and valine, when compared with controls. In the DAT group there were significant correlations between behaviour and CS glutamine; memory and cognitive functions and CSF valine; copying ability and CSF glutamate. CSF/P ratios of glutamine and glutamate correlated with behaviour and copying performances, respectively. The results of this study provide further evidence for a disruption of amino acid metabolism in DAT.
引用
收藏
页码:295 / 304
页数:10
相关论文
共 36 条
[1]  
ADOLFSSON R, 1980, ACTA MED SCAND, V208, P387
[2]   A PRELIMINARY-STUDY OF FREE AMINO-ACIDS IN THE POSTMORTEM TEMPORAL CORTEX FROM ALZHEIMER-TYPE DEMENTIA PATIENTS [J].
ARAI, H ;
KOBAYASHI, K ;
ICHIMIYA, Y ;
KOSAKA, K ;
IIZUKA, R .
NEUROBIOLOGY OF AGING, 1984, 5 (04) :319-321
[3]   THE FLUORODEOXYGLUCOSE F-18 SCAN IN ALZHEIMERS-DISEASE AND MULTI-INFARCT DEMENTIA [J].
BENSON, DF ;
KUHL, DE ;
HAWKINS, RA ;
PHELPS, ME ;
CUMMINGS, JL ;
TSAI, SY .
ARCHIVES OF NEUROLOGY, 1983, 40 (12) :711-714
[4]  
BOWEN DM, 1979, LANCET, V1, P11
[5]   NMDA RECEPTORS - THEIR ROLE IN LONG-TERM POTENTIATION [J].
COLLINGRIDGE, GL ;
BLISS, TVP .
TRENDS IN NEUROSCIENCES, 1987, 10 (07) :288-293
[6]   AMINO-ACID CONCENTRATIONS IN CEREBROSPINAL-FLUID IN PRESENILE AND SENILE DEMENTIA OF ALZHEIMER TYPE AND MULTI-INFARCT DEMENTIA [J].
DEGRELL, I ;
HELLSING, K ;
NAGY, E ;
NIKLASSON, F .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1989, 9 (02) :123-135
[7]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[8]   CORTICAL ABNORMALITIES IN ALZHEIMERS-DISEASE [J].
FOSTER, NL ;
CHASE, TN ;
MANSI, L ;
BROOKS, R ;
FEDIO, P ;
PATRONAS, NJ ;
DICHIRO, G .
ANNALS OF NEUROLOGY, 1984, 16 (06) :649-654
[9]  
GELOT MA, 1990, ANN BIOL CLIN-PARIS, V48, P182
[10]   EXCITATORY AMINO-ACIDS AND ALZHEIMERS-DISEASE [J].
GREENAMYRE, JT ;
YOUNG, AB .
NEUROBIOLOGY OF AGING, 1989, 10 (05) :593-602