ESTRADIOL-INDUCED CONDITIONED TASTE-AVERSION AND PLACE AVERSION IN RATS - SEX-DEPENDENT AND DOSE-DEPENDENT EFFECTS

被引：36

作者：

DEBEUN, R ^{[1
]}

JANSEN, E ^{[1
]}

SMEETS, MAM ^{[1
]}

NIESING, J ^{[1
]}

SLANGEN, JL ^{[1
]}

VANDEPOLL, NE ^{[1
]}

机构：

[1] UNIV UTRECHT,FAC PHARM,3584 CA UTRECHT,NETHERLANDS

来源：

PHYSIOLOGY & BEHAVIOR | 1991年 / 50卷 / 05期

关键词：

ESTRADIOL-17-BETA; CONDITIONED TASTE AVERSION; CONDITIONED PLACE AVERSION; MALE RATS; FEMALE RATS;

D O I：

10.1016/0031-9384(91)90427-P

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Effects of various doses (0-250-mu-g/kg, SC) of estradiol-17-beta (E2) in a two-bottle choice conditioned taste aversion and a two-compartment conditioned place preference procedure were studied in male and female rats. Dose-dependent taste aversion and place aversion effects of E2 were established, and the conditioned taste aversion procedure was found to be more sensitive in detecting aversive properties of E2 than the conditioned place preference procedure. Although aversive properties of E2 were found in both sexes, the effects were clearly more prominent in males as compared to females. From this study, it was concluded that E2 acts as an unconditioned aversive stimulus in both male and female rats capable of gaining control over different types of behavior by associative learning.

引用

页码：995 / 1000

页数：6

共 24 条

[1] SINGLE-TRIAL CONDITIONED PLACE PREFERENCE USING INTRAVENOUS MORPHINE [J].