HOMING RECEPTORS REEXAMINED - MOUSE LECAM-1 (MEL-14 ANTIGEN) IS INVOLVED IN LYMPHOCYTE MIGRATION INTO GUT-ASSOCIATED LYMPHOID-TISSUE

被引：86

作者：

HAMANN, A

JABLONSKIWESTRICH, D

JONAS, P

THIELE, HG

机构：

[1] Department of Immunology, I. Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 12期

关键词：

D O I：

10.1002/eji.1830211205

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Specific recognition molecules ("homing receptors") on lymphocytes are thought to direct selective entry of cells into different organs. The lectin-related cell adhesion molecule LECAM-1 has previously been supposed to mediate lymphocyte entry into peripheral lymph nodes and, partially, mesenteric nodes but not into Peyer's patches. Here we present evidence that in vivo the molecule is also implicated in homing of mouse lymphocytes to Peyer's patches and may have a more general role as homing receptor for high endothelial venules-bearing lymphoid tissue, but not for most non-lymphoid tissue.

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页码：2925 / 2929

页数：5

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