GAS-CHROMATOGRAPHIC HEADSPACE ANALYSIS OF SEVOFLURANE IN BLOOD

被引：23

作者：

WATTS, MT

ESCARZAGA, M

WILLIAMS, CH

机构：

[1] TEXAS TECH UNIV, HLTH SCI CTR,REG ACAD HLTH CTR,SCH MED,DEPT SURG, EL PASO, TX 79905 USA

[2] TEXAS TECH UNIV, HLTH SCI CTR,REG ACAD HLTH CTR,SCH MED, DEPT BIOCHEM, EL PASO, TX 79905 USA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 577卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80250-T

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We have developed a rapid, simple and precise gas chromatographic headspace analysis for sevoflurane in blood which circumvents problems associated with the high volatility and low blood/gas partition coefficient of this anesthetic drug. Blood standards are easily prepared by volumetric addition of a saturated aqueous solution of sevoflurane. Likewise. internal standardization is achieved using a saturated aqueous solution of halothane. Chromatographic conditions are similar to those commonly used for the analysis of blood ethanol. A simple method is also described for the preparation of stable and precise aliquots of quality control materials for this assay.

引用

页码：289 / 298

页数：10

共 20 条

[1] DETERMINATION OF HYDROCARBON ANESTHETICS IN BLOOD BY GAS CHROMATOGRAPHY [J].