INTERNODAL POTASSIUM CURRENTS CAN GENERATE ECTOPIC IMPULSES IN MAMMALIAN MYELINATED AXONS

被引：32

作者：

KAPOOR, R

SMITH, KJ

FELTS, PA

DAVIES, M

机构：

[1] UMDS,DEPT NEUROL,GUYS CAMPUS,ST THOMAS ST,LONDON SE1 9RT,ENGLAND

[2] UMDS,DEPT ANAT & CELL BIOL,LONDON SE1 9RT,ENGLAND

[3] UNIV LONDON,INST NEUROL,DEPT CLIN NEUROL,LONDON,ENGLAND

来源：

BRAIN RESEARCH | 1993年 / 611卷 / 01期

基金：

英国惠康基金;

关键词：

ACTION POTENTIAL; PERIAXONAL SPACE; POTASSIUM CHANNEL; 4-AMINOPYRIDINE; TETRAETHYLAMMONIUM; ECTOPIC FIRING; POSITIVE SYMPTOM;

D O I：

10.1016/0006-8993(93)91790-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Positive clinical symptoms can arise from ectopic action potentials in several disorders of myelinated axons. Here we report that an elevated K+ concentration in the periaxonal, internodal space can cause internodal K+ currents to become excitatory, resulting in slow potential oscillations and associated bursts of ectopic spikes. Ectopic firing may therefore be favoured by conditions in which periaxonal K+ buffering is compromised.

引用

页码：165 / 169

页数：5

共 23 条

[1] HEREDITARY FORM OF SUSTAINED MUSCLE-ACTIVITY OF PERIPHERAL-NERVE ORIGIN CAUSING GENERALIZED MYOKYMIA AND MUSCLE-STIFFNESS [J].