CYTOKINE GENE ACTIVATION AND MODIFIED RESPONSIVENESS TO INTERLEUKIN-2 IN THE BLOOD OF TUBERCULOSIS PATIENTS

被引：76

作者：

SCHAUF, V

ROM, WN

SMITH, KA

SAMPAIO, EP

MEYN, PA

TRAMONTANA, JM

COHN, ZA

KAPLAN, G

机构：

[1] ROCKEFELLER UNIV, CELLULAR PHYSIOL & IMMUNOL LAB, 1230 YORK AVE, NEW YORK, NY 10021 USA

[2] BELLEVUE HOSP CTR, NEW YORK, NY 10016 USA

[3] CORNELL UNIV, MED CTR,NEW YORK HOSP,DEPT MED, DIV PULM DIS & CRIT CARE, NEW YORK, NY 10021 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1993年 / 168卷 / 04期

关键词：

D O I：

10.1093/infdis/168.4.1056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Selected parameters of cellular immunity relating to cytokine gene activation and responsiveness to interleukin-2 (IL-2) were analyzed in 27 patients with active pulmonary tuberculosis and no human immunodeficiency virus type 1 infection. Cytokine mRNAs were not expressed by peripheral blood mononuclear cells (PBMC) of normal controls. In PBMC of tuberculosis patients, messages for IL-1, IL-8, and tumor necrosis factor-alpha were uniformly expressed, whereas PBMC of only 5 of 18 patients expressed IL-6. PBMC of 7 patients (all of those with systemic symptoms) expressed interferon-gamma mRNA and none expressed IL-2 mRNA. Most patients' cells demonstrated IL-4 mRNA. Limiting dilution analysis of IL-2-responsive cells in PBMC revealed that tuberculosis patients had 10-fold fewer IL-2-responsive cells than did controls.

引用

页码：1056 / 1059

页数：4

共 14 条

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