POSITRON EMISSION TOMOGRAPHY SHOWS HIGH SPECIFIC UPTAKE OF RACEMIC C-11 LABELED NOREPINEPHRINE IN THE PRIMATE HEART

被引：18

作者：

FARDE, L ^{[1
]}

HALLDIN, C ^{[1
]}

NAGREN, K ^{[1
]}

SUHARA, T ^{[1
]}

KARLSSON, P ^{[1
]}

SCHOEPS, KO ^{[1
]}

SWAHN, CG ^{[1
]}

BONE, D ^{[1
]}

机构：

[1] UNIV TURKU,CTR CYCLOTRON PET,SF-20500 TURKU,FINLAND

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1994年 / 21卷 / 04期

关键词：

NOREPINEPHRINE; POSITRON EMISSION TOMOGRAPHY; HEART; MONKEYS;

D O I：

10.1007/BF00947971

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

(-)-Norepinephrine is the predominant neurotransmitter of the sympathetic innervation of the heart. Racemic norepinephrine was labelled with carbon-11 and injected i.v. into Cynomolgus monkeys. Five minutes after injection there was a more than tenfold higher radioactivity in the heart than in adjacent tissue. Pretreatment with the norepinephrine reuptake inhibitor desipramine reduced the uptake by more than 80%. The high specific uptake of racemic [C-11]norepinephrine indicates that enatiomerically pure (-)-[C-11]norepinephrine has promising potential for detailed mapping of the sympathetic innervation of the human myocardium.

引用

页码：345 / 347

页数：3

共 11 条

[1]

AXELROD J, 1960, ADRENERGIC MECHANISM, P28

[2]

DING YS, 1993, J NUCL MED, V34, P619

[3] RADIOPHARMACEUTICALS .12. NEW RAPID SYNTHESIS OF CARBON-11 LABELED NOREPINEPHRINE HYDROCHLORIDE [J].