AN ALTERNATIVE ROUTE FOR PREPARATION OF ALPHA-METHYLPHOSPHONYL-BETA,GAMMA-DIPHOSPHATES OF THYMIDINE DERIVATIVES

被引：9

作者：

ARZUMANOV, AA

DYATKINA, NB

机构：

[1] Eiigelliardt Institute of Molecular Biology, Russian Academy of Sciences, 117984 Moscow

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 05期

关键词：

D O I：

10.1080/15257779408011876

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An alternative ''one pot'' synthesis of alpha-methylphosphonyl-beta,gamma-diphosphates of thymidine and 3'-azidothymidine is proposed. p-Toluene-sulphonic acid was used as desililating agent for triphosphate analogues.

引用

页码：1031 / 1037

页数：7

共 6 条

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[2] DYATKINA N, 1987, BIOPHOSPHATES THEIR, P395
[3] DYATKINA NB, 1988, BIOORG KHIM+, V14, P815
[4] ENZYMATIC-SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING METHYLPHOSPHONATE INTERNUCLEOTIDE LINKAGES
HIGUCHI, H
ENDO, T
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[J]. BIOCHEMISTRY, 1990, 29 (37) : 8747 - 8753
[5] LUDWIG J, 1981, ACTA BIOCHIM BIOPHYS, V16, P131
[6] FORMATION OF PHOSPHONESTER BONDS CATALYZED BY DNA-POLYMERASE
VICTOROVA, LS
DYATKINA, NB
MOZZHERIN, DJ
ATRAZHEV, AM
KRAYEVSKY, AA
KUKHANOVA, MK
[J]. NUCLEIC ACIDS RESEARCH, 1992, 20 (04) : 783 - 789

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