HEMOGLOBIN-BASED BLOOD SUBSTITUTES AND SEPSIS

被引：51

作者：

GRIFFITHS, E

CORTES, A

GILBERT, N

STEVENSON, P

MACDONALD, S

PEPPER, D

机构：

[1] NATL INST BIOL STAND & CONTROLS,S MIMMS,HERTS,ENGLAND

[2] SCOTTISH NATL BLOOD TRANSFUS SERV,NATL SCI LAB,EDINBURGH,MIDLOTHIAN,SCOTLAND

来源：

LANCET | 1995年 / 345卷 / 8943期

关键词：

D O I：

10.1016/S0140-6736(95)90168-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An important concern that has received little attention is the possible increased susceptibility to bacterial infections of patients infused with cell-free haemoglobin-based blood substitutes. We show that pyridoxalated polymerised human haemoglobin promotes fulminating Escherichia coli septicaemia in mice, which draws attention to the potential danger of such products in the clinic.

引用

页码：158 / 160

页数：3

共 10 条

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