HUMAN RECOMBINANT NERVE GROWTH-FACTOR REPLACES DEFICIENT NEUROTROPHIC SUPPORT IN THE DIABETIC RAT

被引：107

作者：

FERNYHOUGH, P ^{[1
]}

DIEMEL, LT ^{[1
]}

HARDY, J ^{[1
]}

BREWSTER, WJ ^{[1
]}

MOHIUDDIN, L ^{[1
]}

TOMLINSON, DR ^{[1
]}

机构：

[1] UNIV LONDON QUEEN MARY & WESTFIELD COLL,DEPT PHARMACOL,LONDON E1 4NS,ENGLAND

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1995年 / 7卷 / 05期

基金：

英国惠康基金;

关键词：

AXONAL TRANSPORT; CALCITONIN GENE-RELATED PEPTIDE; DIABETES; DIABETIC NEUROPATHY; NERVE GROWTH FACTOR; SUBSTANCE P;

D O I：

10.1111/j.1460-9568.1995.tb01098.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Manipulation of neurotrophic support is a developing strategy for new therapy aimed at neurodegenerative diseases. This study demonstrates reduced content and retrograde transport of endogenous nerve growth factor (NGF) in sciatic nerve of diabetic rats. There were also reductions in the diabetic rats in NGF protein and mRNA in skin and muscle of the hindlimb. These deficits correlated with reductions in substance P and calcitonin gene-related peptide-both products of NGF-influenced genes in primary afferents. These manifestations of deficient neurotrophic support were corrected by intensive insulin treatment and surmounted by administration of exogenous human recombinant NGF in a dose-related manner. Impaired neurotrophic support may, therefore, participate in the pathogenesis of diabetic and other peripheral neuropathies.

引用

页码：1107 / 1110

页数：4

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