THE EFFECT OF BUDESONIDE (RHINOCORT(R)) IN THE TREATMENT OF SMALL AND MEDIUM-SIZED NASAL POLYPS

被引：91

作者：

JOHANSEN, LV

ILLUM, P

KRISTENSEN, S

WINTHER, L

PETERSEN, SV

SYNNERSTAD, B

机构：

[1] JOSEPHS HOSP,SCT,DEPT OTORHINOLARYNGOL,ESBJERG,DENMARK

[2] CENT HOSP,DEPT OTORHINOLARYNGOL,HOLSTEBRO,DENMARK

[3] FUNEN CTY UNIV HOSP,DEPT OTORHINOLARYNGOL,ODENSE,DENMARK

[4] HOSP VASTERVIK,DEPT OTORHINOLARYNGOL,VASTERVIK,DENMARK

来源：

CLINICAL OTOLARYNGOLOGY | 1993年 / 18卷 / 06期

关键词：

NASAL POLYPOSIS; BUDESONIDE; GLUCOCORTICOID; STEROID; AEROSOL; PUMP SPRAY;

D O I：

10.1111/j.1365-2273.1993.tb00628.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The objectives of this study were to determine if the size of nasal polyps could be assessed in a reproducible way and to study the effect of budesonide in patients suffering from eosinophilic nasal polyposis with small and medium sized polyps. Ninety-one patients entered the study. Budesonide 200 mug b.i.d. (aerosol or aqua) and placebo (aerosol or aqua) were compared in a 3-month double-blind, multi-centre, randomized study. Efficacy was measured by an assessment of polyp size, nasal peak-flow index and the patient's assessment of nasal symptoms. The conclusions were that the size of polyps could be assessed in a reproducible way, and that budesonide delivered either as a water-based suspension or as an aerosol is effective in the treatment of patients with small and medium sized polyps.

引用

页码：524 / 527

页数：4

共 9 条

[1]

DEUSCHL H, 1977, Rhinology (Utrecht), V15, P17

[2]

DRETTNER B, 1982, Rhinology (Utrecht), V20, P149

[3] BUDESONIDE NASAL SPRAY AS PROPHYLACTIC TREATMENT AFTER POLYPECTOMY (A DOUBLE-BLIND CLINICAL-TRIAL) [J].