EFFECT OF INDOMETHACIN ON COLLAGEN-METABOLISM OF RAT FRACTURE CALLUS INVITRO

被引：29

作者：

RO, J ^{[1
]}

LANGELAND, N ^{[1
]}

SANDER, J ^{[1
]}

机构：

[1] UNIV OSLO, RIKSHOSP, INST SURG RES, OSLO, NORWAY

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1978年 / 49卷 / 04期

关键词：

Anti-inflammatory agents; Bone; Callus; Fractures; Indomethacin; Rats;

D O I：

10.3109/17453677809050082

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The collagen metabolism of callus tissue from closed, non-immobilized rat femoral fractures was studied in vitro after in vivo treatment with indomethacin 2 mg/kg/day for 6, 9 and 12 days after fracture. Total hydroxyproline synthesis and incorporation of hydroxyproline into collagen were found to be significantly increased after indomethacin treatment, whereas no significant difference was found regarding collagen resorption. the results Surggest that the recently demonstrated inhibition of fracture healing by indomethacin is not brought about by an inhibition of collagen synthesis. © 1978 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：323 / 328

页数：6

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