INFLUENCE OF PHOSPHATIDYLCHOLINE ON INTRAABDOMINAL ADHESION FORMATION AND PERITONEAL-MACROPHAGES

被引：19

作者：

ROZGA, J ^{[1
]}

ANDERSSON, R ^{[1
]}

SRINIVAS, U ^{[1
]}

AHREN, B ^{[1
]}

BENGMARK, S ^{[1
]}

机构：

[1] UNIV LUND, DEPT CLIN CHEM, S-22185 LUND, SWEDEN

来源：

NEPHRON | 1990年 / 54卷 / 02期

关键词：

Adhesions; Macrophage; Oxygen-free radicals; Peritoneal dialysis; Peritoneum; Phosphatidylcholine;

D O I：

10.1159/000185833

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Phosphatidylcholine (PC) is the predominant constituent of the surface-active material coating peritoneal mesothelium. Its effects on surgically induced adhesion formation and on peritoneal macrophage viability and superoxide production were studied in rats. Rats treated with intraperitoneal PC liposomes showed more adhesions than controls (p < 0.01). In vitro incubation with PC had no effect on macrophage viability, but significantly diminished superoxide production (p < 0.05 and less). It is concluded that PC in its insoluble form is of no value in the prophylaxis of adhesions after abdominal and pelvic surgery and that with the use of the intraperitoneal route it is probably contraindicated in patients undergoing continuous ambulatory peritoneal dialysis.

引用

页码：134 / 138

页数：5

共 35 条

[1]

Alobaidi H M, 1986, Nephrol Dial Transplant, V1, P16

[2] The chemistry of the lipoids of tubercle bacilli [J].

Anderson, RJ .

PHYSIOLOGICAL REVIEWS, 1932, 12 (02) :0166-0189

[3]

BABIOR BM, 1984, BLOOD, V64, P959

[4]

BROWDER W, 1988, SURGERY, V104, P224

[5]

DIAMOND M P, 1987, Microsurgery, V8, P103, DOI 10.1002/micr.1920080215

[6] PHOSPHATIDYLCHOLINE AND PERITONEAL TRANSPORT DURING PERITONEAL-DIALYSIS [J].

DIPAOLO, N ;

BUONCRISTIANI, U ;

CAPOTONDO, L ;

GAGGIOTTI, E ;

DEMIA, M ;

ROSSI, P ;

SANSONI, E ;

BERNINI, M .

NEPHRON, 1986, 44 (04) :365-370

[7] EFFECTS OF THE COMPOSITION OF PERITONEAL-DIALYSIS FLUID ON CHEMI-LUMINESCENCE, PHAGOCYTOSIS, AND BACTERICIDAL ACTIVITY INVITRO [J].

DUWE, AK ;

VAS, SI ;

WEATHERHEAD, JW .

INFECTION AND IMMUNITY, 1981, 33 (01) :130-135

[8] THE CAUSES AND PREVENTION OF INTESTINAL ADHESIONS [J].

ELLIS, H .

BRITISH JOURNAL OF SURGERY, 1982, 69 (05) :241-243

[9]

ELSBACH P, 1983, REV INFECT DIS, V5, P843

[10]

Fallon JT, 1937, CAN MED ASSOC J, V36, P223

← 1 2 3 4 →