PERFUSION OF RAT COLON WITH SENNOSIDES, RHEIN AND RHEINANTHRONE - CONCENTRATION-RELATED HISTAMINE-RELEASE

被引：6

作者：

AUTORE, G

CALIENDO, G

PEPE, A

CAPASSO, F

机构：

[1] DEPT EXPTL PHARMACOL,VIA DOMENICO MONTESANO 49,I-80131 NAPLES,ITALY

[2] DEPT PHARMACEUT CHEM,I-80131 NAPLES,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 191卷 / 01期

关键词：

Colon (rat); Histamine; Rhein; Rheinanthrone; Sennosides;

D O I：

10.1016/0014-2999(90)94101-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rat colon perfused intraluminally in vitro and in vivo released histamine into the perfusates. Histamine release was increased by rhein 0.1-10 μg/ml and much more by rheinanthrone 0.1-10 μg/ml but not by sennosides A or B 1-10 μg/ml. The effect of rhein and rheinanthrone was reduced by tritoqualine 20 mg/kg. This raises the possibility that laxation by senna and its derivatives involves histamine formation. © 1990.

引用

页码：97 / 99

页数：3

共 10 条

[1]

ANTON AH, 1969, J PHARMACOL EXP THER, V166, P285

[2] LAXATIVES AND THE PRODUCTION OF AUTACOIDS BY RAT COLON [J].