REGIONS OF THE POLYOMA GENOME CODING FOR T-ANTIGENS

被引：14

作者：

HUNTER, T ^{[1
]}

HUTCHINSON, MA ^{[1
]}

ECKHART, W ^{[1
]}

FRIEDMANN, T ^{[1
]}

ESTY, A ^{[1
]}

LAPORTE, P ^{[1
]}

DEININGER, P ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT PEDIAT,LA JOLLA,CA 92093

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 7卷 / 08期

关键词：

D O I：

10.1093/nar/7.8.2275

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The early region of the polyoma genoma encodee three T antigens. We have analyzed the organizetion of the coding regione for the T antigens, using the nucleotide sequence of polyoma DNA and peptides derived from purified, radiolabeled T antigene, separated by two-dimensional electrophoresis and chromatography. We compared the peptides, predicted from the nucleotide sequence of the DNA, with those derived from the purified T antigens. We also compared chemically synthesized peptides, predicted from the DNA sequence, with observed peptides. The results show that the three polyoma T antigens are encoded in overlapping regions of the viral DNA, translated, in part, in two different reading frames. © 1979 Information Retrieval Limited.

引用

页码：2275 / 2288

页数：14

共 22 条

[1] OVERLAPPING GENES IN BACTERIOPHAGE-PSIX174 [J].

BARRELL, BG ;

AIR, GM ;

HUTCHISON, CA .

NATURE, 1976, 264 (5581) :34-41

[2] COMPLEMENTATION BETWEEN TEMPERATURE-SENSITIVE (TS) AND HOST RANGE NON-TRANSFORMING (HR-T) MUTANTS OF POLYOMA-VIRUS [J].

ECKHART, W .

VIROLOGY, 1977, 77 (02) :589-597

[3] COMPLETE NUCLEOTIDE-SEQUENCE OF SV40 DNA [J].

FIERS, W ;

CONTRERAS, R ;

HAEGEMAN, G ;

ROGIERS, R ;

VANDEVOORDE, A ;

VANHEUVERSWYN, H ;

VANHERREWEGHE, J ;

VOLCKAERT, G ;

YSEBAERT, M .

NATURE, 1978, 273 (5658) :113-120

[4] HR-T AND TS-A - 2 EARLY GENE FUNCTIONS OF POLYOMA-VIRUS [J].

FLUCK, MM ;

STANELONI, RJ ;

BENJAMIN, TL .

VIROLOGY, 1977, 77 (02) :610-624

[5] AMINO-ACID SEQUENCE HOMOLOGY BETWEEN POLYOMA AND SV40 TUMOR ANTIGENS DEDUCED FROM NUCLEOTIDE-SEQUENCES [J].

FRIEDMANN, T ;

DOOLITTLE, RF ;

WALTER, G .

NATURE, 1978, 274 (5668) :291-293

[6] NUCLEOTIDE-SEQUENCE AND GENOME ORGANIZATION OF THE POLYOMA EARLY REGION - EXTENSIVE NUCLEOTIDE AND AMINO-ACID HOMOLOGY WITH SV40 [J].

FRIEDMANN, T ;

ESTY, A ;

LAPORTE, P ;

DEININGER, P .

CELL, 1979, 17 (03) :715-724

[7] TRANSLATION OF POLYOMA VIRUS-T ANTIGENS INVITRO [J].

HUNTER, T ;

HUTCHINSON, MA ;

ECKHART, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (12) :5917-5921

[8]

HUTCHINSON MA, 1978, CELL, V15, P67

[9] CHARACTERIZATION OF POLYOMA VIRUS-T ANTIGEN [J].

ITO, Y ;

SPURR, N ;

DULBECCO, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (03) :1259-1263

[10] VIRUS-SPECIFIC PROTEINS IN PLASMA-MEMBRANE OF CELLS LYTICALLY INFECTED OR TRANSFORMED BY POLYOMA-VIRUS [J].

ITO, Y ;

BROCKLEHURST, JR ;

DULBECCO, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (10) :4666-4670

← 1 2 3 →