CALYCULIN-E, CALYCULIN-F, CALYCULIN-G, AND CALYCULIN-H, ADDITIONAL INHIBITORS OF PROTEIN PHOSPHATASE-1 AND PHOSPHATASE-2A, FROM THE MARINE SPONGE DISCODERMIA-CALYX

被引：93

作者：

MATSUNAGA, S

FUJIKI, H

SAKATA, D

FUSETANI, N

机构：

[1] UNIV TOKYO,FAC AGR,MARINE BIOCHEM LAB,BUNKYO KU,TOKYO 113,JAPAN

[2] NATL CANC CTR,RES INST,DIV CANC PREVENT,CHUO KU,TOKYO 104,JAPAN

来源：

TETRAHEDRON | 1991年 / 47卷 / 18-19期

关键词：

D O I：

10.1016/S0040-4020(01)96031-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Calyculins E (5), F (6), G (7), and H (8) were isolated from the marine sponge Discodermia calyx. The structures for 5-8 were assigned on the basis of the interpretation of spectral data. These novel calyculins were potent inhibitors of protein phosphatases 1 and 2A: effective doses for 50% inhibition of protein phosphatases 2A activity for these calyculins were 2.7-6.0 nM.

引用

页码：2999 / 3006

页数：8

共 10 条

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