SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF [1-N4-DIMETHYL-ASPARAGINE]-ANGIOTENSIN-II

被引：3

作者：

CORDOPATIS, P ^{[1
]}

BRISON, J ^{[1
]}

DIRKX, J ^{[1
]}

THEODOROPOULOS, D ^{[1
]}

机构：

[1] UNIV MONS,BIOL CHEM LAB,B-7000 MONS,BELGIUM

来源：

EXPERIENTIA | 1979年 / 35卷 / 07期

关键词：

D O I：

10.1007/BF01955103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[1-N4-Dimethyl-asparagine]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue gave rat blood pressure about 70% relative potency to Hypertensin (Ciba). Rabbit aorta strips gave intrinsic activity αE=1, a PD2 of 6.92±0.09 and an affinity relative to [Asn1]-angiotensin II of 6.5%. © 1979 Birkhäuser Verlag.

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页码：849 / 851

页数：3

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