NMDA AND KAINIC ACID RECEPTORS HAVE A COMPLEMENTARY DISTRIBUTION TO AMPA RECEPTORS IN THE HUMAN CEREBELLUM

被引:18
作者
JANSEN, KLR [1 ]
FAULL, RLM [1 ]
DRAGUNOW, M [1 ]
机构
[1] UNIV AUCKLAND,SCH MED,DEPT PHARMACOL,AUCKLAND,NEW ZEALAND
基金
英国医学研究理事会;
关键词
Autoradiography; Cerebellum; Human; Kainic acid receptor; N-Methyl-d-aspartate receptor; α-Amino-3-hydroxy-S-methyl-4-isoxazole propionic acid receptor;
D O I
10.1016/0006-8993(90)91783-D
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The distributions of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-S-methyl-4-isoxazole propionic acid (AMPA) and kainic acid (KA) receptors were determined in the human cerebellum using autoradiography. In contrast to the cerebral cortex, where KA receptors have a complementary distribution to NMDA and AMPA receptors, AMPA receptors were concentrated in the cerebellar molecular layer while NMDA and KA receptors were concentrated in the granular layer. © 1990.
引用
收藏
页码:351 / 354
页数:4
相关论文
共 21 条
[1]   IMMUNOHISTOCHEMICAL LOCALIZATION OF GLUTAMATE, GLUTAMINASE AND ASPARTATE-AMINOTRANSFERASE IN NEURONS OF THE PONTINE NUCLEI OF THE RAT [J].
BEITZ, AJ ;
LARSON, AA ;
MONAGHAN, P ;
ALTSCHULER, RA ;
MULLETT, MM ;
MADL, JE .
NEUROSCIENCE, 1986, 17 (03) :741-753
[2]  
CHA JJ, 1988, J NEUROCHEM, V51, P489
[3]   NMDA RECEPTORS - THEIR ROLE IN LONG-TERM POTENTIATION [J].
COLLINGRIDGE, GL ;
BLISS, TVP .
TRENDS IN NEUROSCIENCES, 1987, 10 (07) :288-293
[4]   ANATOMICAL ORGANIZATION OF EXCITATORY AMINO-ACID RECEPTORS AND THEIR PATHWAYS [J].
COTMAN, CW ;
MONAGHAN, DT ;
OTTERSEN, OP ;
STORMMATHISEN, J .
TRENDS IN NEUROSCIENCES, 1987, 10 (07) :273-280
[5]   STIMULATION OF RAT CEREBELLAR GUANOSINE 3',5'-CYCLIC-MONOPHOSPHATE (CYCLIC-GMP) LEVELS - EFFECTS OF AMINO-ACID ANTAGONISTS [J].
FOSTER, GA ;
ROBERTS, PJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1981, 74 (03) :723-729
[6]  
GREENAMYRE JT, 1985, J PHARMACOL EXP THER, V233, P254
[7]  
GREENAMYRE JT, 1984, J NEUROSCI, V4, P2133
[8]   GLUTAMIC-ACID - STRONG CANDIDATE AS NEUROTRANSMITTER OF CEREBELLAR GRANULE CELL [J].
HUDSON, DB ;
VALCANA, T ;
BEAN, G ;
TIMIRAS, PS .
NEUROCHEMICAL RESEARCH, 1976, 1 (01) :73-81
[9]   CLIMBING FIBER INDUCED DEPRESSION OF BOTH MOSSY FIBER RESPONSIVENESS AND GLUTAMATE SENSITIVITY OF CEREBELLAR PURKINJE-CELLS [J].
ITO, M ;
SAKURAI, M ;
TONGROACH, P .
JOURNAL OF PHYSIOLOGY-LONDON, 1982, 324 (MAR) :113-134
[10]  
Ito M., 1984, CEREBELLUM NEURAL CO