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IMPROVED LIPASE-MEDIATED RESOLUTION OF MANDELIC-ACID ESTERS BY MULTIVARIATE INVESTIGATION OF EXPERIMENTAL FACTORS

被引：20
作者：
EBERT, C
FERLUGA, G
GARDOSSI, L
GIANFERRARA, T
LINDA, P
机构：
[1] Dipartimento di Scienze Farmaceutiche, Università Trieste, 34127 Trieste
来源：
TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 07期
关键词：
D O I：
10.1016/S0957-4166(00)82188-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Lipase catalyzed stereoselective acylation of butyl mandelate was studied. The determining role of solvent and acylating agent was pointed out and a considerable inhibitory effect due to mandelic acid was observed by screening different lipases. Finally, the performance of the reaction was appreciably improved thank to a multivariate approach.
引用
收藏
页码：903 / 912
页数：10
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