MALIGNANT TRANSFORMATION BY A MUTANT OF THE IFN-INDUCIBLE DSRNA-DEPENDENT PROTEIN-KINASE

被引：530

作者：

KOROMILAS, AE

ROY, S

BARBER, GN

KATZE, MG

SONENBERG, N

机构：

[1] MCGILL UNIV, FAC MED, DEPT BIOCHEM, MONTREAL H3G 1Y6, QUEBEC, CANADA

[2] MCGILL UNIV, FAC MED, MCGILL CANC CTR, MONTREAL H3G 1Y6, QUEBEC, CANADA

[3] UNIV WASHINGTON, SCH MED, DEPT MICROBIOL, SEATTLE, WA 98195 USA

来源：

SCIENCE | 1992年 / 257卷 / 5077期

关键词：

D O I：

10.1126/science.1382315

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The double-stranded RNA-dependent protein kinase (dsRNA-PK) is thought to be a key mediator of the antiviral and antiproliferative effects of interferons (IFNs). Studies examining the physiological function of the kinase suggest that it participates in cell growth and differentiation by regulating protein synthesis. Autophosphorylation and consequent activation of dsRNA-PK in vitro and in vivo result in phosphorylation of the alpha-subunit of eukaryotic initiation factor-2 (eIF-2) and inhibition of protein synthesis. Expression of a functionally defective mutant of human dsRNA-PK in NIH 3T3 cells resulted in malignant transformation, suggesting that dsRNA-PK may function as a suppressor of cell proliferation and tumorigenesis.

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页码：1685 / 1689

页数：5

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