RESEARCH ON ANTIBACTERIAL AND ANTIFUNGAL AGENTS .16. SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF 1-[ALPHA-(1-NAPHTHYL)BENZYL]IMIDAZOLE DERIVATIVES AND RELATED 2-NAPHTHYL ISOMERS

被引：17

作者：

ARTICO, M

STEFANCICH, G

SILVESTRI, R

MASSA, S

APUZZO, G

ARTICO, M

SIMONETTI, G

机构：

[1] UNIV TRIESTE,DIPARTIMENTO SCI FARMACEUT,I-34127 TRIESTE,ITALY

[2] UNIV ROME LA SAPIENZA,FAC FARM,IST MICROBIOL,I-00185 ROME,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 07期

关键词：

ANTIFUNGAL AGENTS; 1-[ALPHA-(NAPHTHYL)BENZYL]IMIDAZOLES; BIFONAZOLE ANALOGS;

D O I：

10.1016/0223-5234(92)90089-J

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

引用

页码：693 / 699

页数：7

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