PHARMACOLOGICAL CHARACTERIZATION OF BEHAVIORAL-RESPONSES TO SK-AND-F-83959 IN RELATION TO D-1-LIKE DOPAMINE-RECEPTORS NOT LINKED TO ADENYLYL-CYCLASE

被引:83
作者
DEVENEY, AM [1 ]
WADDINGTON, JL [1 ]
机构
[1] ROYAL COLL SURGEONS IRELAND,DEPT CLIN PHARMACOL,DUBLIN 2,IRELAND
关键词
DOPAMINE D-1 RECEPTORS; SK-AND-F; 83959; SCH; 23390; BW; 737C; GROOMING BEHAVIOR; D-1-LIKE RECEPTORS; ADENYLYL CYCLASE;
D O I
10.1111/j.1476-5381.1995.tb16420.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 Behavioural responses to the new benzazepine derivative, SK&F 83959, a compound that both fails to stimulate adenylyl cyclase and inhibits the stimulation of adenylyl cyclase induced by dopamine, were characterized in detail. 2 In rat striatal membrane preparations, radioligand binding studies with [H-3]-SCH 23390 and [H-3]-spiperone indicated SK&F 83959 had a high affinity and >250 fold selectivity for D-1 over D-2 receptors. 3 Using a rapid time-sampling behavioural check list technique, SK&F 83959 (0.01-1.25 mg kg(-1)) induced grooming in the manner of all known D-1 receptor agonists, together with some vacuous chewing, which declined at higher doses with the emergence of directed chewing and rearing as an adjunct to prominent sniffing; no stereotyped behaviour was evident. 4 Grooming to SK&F 83959 (0.05 mg kg(-1)) was blocked by the selective D-1 receptor antagonists, SCH 23390 (0.01-1.0 mg kg(-1)) and BW 737C (0.04-5.0 mg kg(-1)) and was attenuated by the selective D-2 receptor antagonist, YM 09151-2 (0.005-0.5 mg kg(-1)); vacuous chewing to SK&F 83959 was not influenced by either SCH 23390 or BW 737C and was enhanced by YM 09151-2. 5 The paradoxical induction of typical D-1 receptor agonist-induced grooming by SK&F 83959, an agent satisfying criteria for a D-1 receptor antagonist as classically defined, together with its blockade by typical D-1 antagonists, strongly suggests mediation via a 'D-1-like' site that appears to respond similarly to agents independent of whether they exert agonist or antagonist actions at the classical adenylyl cyclase-coupled D-1 receptor. This direct functional evidence for a 'D-1-like' site that is not linked to adenylyl cyclase readily complements neurochemical data suggesting the existence of a cyclase-independent 'D-1-like' receptor that may be coupled to phosphoinositide hydrolysis.
引用
收藏
页码:2120 / 2126
页数:7
相关论文
共 41 条
[1]   DOPAMINE RECEPTOR SUBTYPES - BEYOND THE D1/D2 CLASSIFICATION [J].
ANDERSEN, PH ;
GINGRICH, JA ;
BATES, MD ;
DEARRY, A ;
FALARDEAU, P ;
SENOGLES, SE ;
CARON, MG .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (06) :231-236
[2]   RELATIVE DOPAMINE D1 AND D2 RECEPTOR AFFINITY AND EFFICACY DETERMINE WHETHER DOPAMINE AGONISTS INDUCE HYPERACTIVITY OR ORAL STEREOTYPY IN RATS [J].
ARNT, J ;
BOGESO, KP ;
HYTTEL, J ;
MEIER, E .
PHARMACOLOGY & TOXICOLOGY, 1988, 62 (03) :121-130
[3]   PARTIAL AND FULL DOPAMINE D1-RECEPTOR AGONISTS IN MICE AND RATS - RELATION BETWEEN BEHAVIORAL-EFFECTS AND STIMULATION OF ADENYLATE-CYCLASE ACTIVITY INVITRO [J].
ARNT, J ;
HYTTEL, J ;
SANCHEZ, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 213 (02) :259-267
[4]  
BARLOW RB, 1983, BIODATA HANDLING MIC
[5]   ACTIVATION OF THE 5-HT1C RECEPTOR EXPRESSED IN XENOPUS OOCYTES BY THE BENZAZEPINES SCH-23390 AND SKF-38393 [J].
BRIGGS, CA ;
POLLOCK, NJ ;
FRAIL, DE ;
PAXSON, CL ;
RAKOWSKI, RF ;
KANG, CH ;
KEBABIAN, JW .
BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (04) :1038-1044
[6]  
CIVELLI O, 1993, ANN REV PHARM TOXICO, V32, P281
[7]   DRUGS ACTING AT D-1 AND D-2 DOPAMINE-RECEPTORS INDUCE IDENTICAL PURPOSELESS CHEWING IN RATS WHICH CAN BE DIFFERENTIATED BY CHOLINERGIC MANIPULATION [J].
COLLINS, P ;
BROEKKAMP, CLE ;
JENNER, P ;
MARSDEN, CD .
PSYCHOPHARMACOLOGY, 1991, 103 (04) :503-512
[8]   D-1-DOPAMINE RECEPTORS AND THE TOPOGRAPHY OF UNCONDITIONED MOTOR BEHAVIOR - STUDIES WITH THE SELECTIVE, FULL EFFICACY BENZAZEPINE D-1-AGONIST SKF-83189 [J].
DALY, SA ;
WADDINGTON, JL .
JOURNAL OF PSYCHOPHARMACOLOGY, 1992, 6 (01) :50-60
[9]   BEHAVIORAL EVIDENCE FOR D-1-LIKE DOPAMINE-RECEPTOR SUBTYPES IN RAT-BRAIN USING THE NEW ISOCHROMAN AGONIST A-68930 AND ISOQUINOLINE ANTAGONIST BW-737C [J].
DALY, SA ;
WADDINGTON, JL .
PSYCHOPHARMACOLOGY, 1993, 113 (01) :45-50
[10]   THE EFFECTS OF CLOZAPINE ON BEHAVIORAL-RESPONSES TO THE SELECTIVE D-1-LIKE DOPAMINE-RECEPTOR AGONIST, A-68930, AND TO THE SELECTIVE D-2-LIKE AGONIST, RU-24213 [J].
DALY, SA ;
WADDINGTON, JL .
BRITISH JOURNAL OF PHARMACOLOGY, 1994, 113 (03) :839-844