THE CONFORMATION-DEPENDENT LIPOPHILICITY OF MORPHINE GLUCURONIDES AS CALCULATED FROM THEIR MOLECULAR LIPOPHILICITY POTENTIAL

被引：58

作者：

GAILLARD, P ^{[1
]}

CARRUPT, PA ^{[1
]}

TESTA, B ^{[1
]}

机构：

[1] UNIV LAUSANNE,BEP,ECOLE PHARMAC,INST CHIM THERAPEUT,CH-1015 LAUSANNE,SWITZERLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(01)80191-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A whole range of conformers of morphine-6-0-glucuronide and morphine 3-0-glucuronide were examined for their theoretical log P values using the molecular lipophilicity potential method. The results substantiate the ''chameleonic'' behavior of morphine glucuronides to exist in water as hydrophilic, extended conformers, and in lipidic media as folded, more lipophilic conformers.

引用

页码：737 / 742

页数：6

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