AN ATP-SENSITIVE POTASSIUM CHANNEL BLOCKER DECREASES DIAPHRAGMATIC CIRCULATION IN ANESTHETIZED DOGS

被引:21
作者
COMTOIS, A [1 ]
SINDERBY, C [1 ]
COMTOIS, N [1 ]
GRASSINO, A [1 ]
RENAUD, JM [1 ]
机构
[1] UNIV MONTREAL,NOTRE DAME HOSP,MONTREAL H2L 4M1,PQ,CANADA
关键词
SMOOTH MUSCLE; BLOOD FLOW; CIRCULATION;
D O I
10.1152/jappl.1994.77.1.127
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The goal of this study was to determine whether in the dog ATP-sensitive K+ channels blocked with glibenclamide affect diaphragmatic blood flow [phrenic arterial blood flow (Qpa)] during both spontaneous breathing at rest and increased diaphragmatic activity. A control group (no glibenclamide; n = 4) and an experimental group (50 mg/kg of glibenclamide; n = 5) were studied. During spontaneous breathing at rest, Qpa was 15.0 ml.min(-1).100 g(-1) and decreased by 5% in the presence of glibenclamide. Diaphragmatic pacing (30 min(-1)) generated by phrenic nerve pacing produced an initial diaphragmatic tension-time index of 0.25 in both groups. A 50% decay in transdiaphragmatic pressure was reached at 165 s in the experimental group compared with 421 s in the control group. Diaphragmatic pacing increased Qpa by 46% in the experimental group and 65% in the control group, yielding a 63% greater vascular resistance in the experimental group. Phrenic vein K+ content at rest was unchanged by the presence of glibenclamide, being 3.6 +/- 0.16 mmol/l compared with 3.5 + 0.19 mmol/l in the control group. Phrenic nerve pacing in the control group produced a 13% increase in phrenic vein K+ content, whereas in the experimental group a 16% decrease was observed. We suggest that ATP-sensitive K+ channels play an important role in the modulation of Qpa.
引用
收藏
页码:127 / 134
页数:8
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