SIGNAL-TRANSDUCTION - REGULATION OF CAMP CONCENTRATION IN CARDIAC-MUSCLE BY CALMODULIN-DEPENDENT CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE

被引:13
作者
SHARMA, RK [1 ]
机构
[1] UNIV SASKATCHEWAN,ROYAL UNIV HOSP,SASKATOON CANC CTR,SASKATOON,SK S7N 0W0,CANADA
关键词
SIGNAL TRANSDUCTION; CALMODULIN; PHOSPHODIESTERASE; CA2+; CAMP;
D O I
10.1007/BF01076583
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The bovine heart calmodulin-dependent phosphodiesterase can be phosphorylated by cAMP-dependent protein kinase, resulting in a decrease in the enzyme's affinity for calmodulin. The phosphorylation of calmodulin-dependent phosphodiesterase is blocked by Ca2+ and calmodulin and reversed by the calmodulin-dependent phosphatase. The dephosphorylation is accompanied by an increase in the affinity of the phosphodiesterase for calmodulin. The CaM-dependent phosphodiesterase isozymes of heart and brain are regulated by calmodulin, but the affinity for calmodulin are different. Furthermore, the bovine heart CaM-dependent phosphodiesterase isozyme in stimulated at much lower Ca2+ concentration than the bovine brain isozymes. Results from this study suggest that the activity of this phosphodiesterase is precisely regulated by cross-talk between Ca2+ and cAMP signalling pathways.
引用
收藏
页码:241 / 247
页数:7
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