DIFFERENCE IN UPTAKE, ELIMINATION, AND METABOLISM IN EXPOSURE TO TRICHLOROETHYLENE, 1,1,1-TRICHLOROETHANE AND TETRACHLOROETHYLENE

被引:49
作者
MONSTER, AC [1 ]
机构
[1] UNIV AMSTERDAM, FAC MED, INST OCCUPAT & ENVIRONM HLTH, CORONEL LAB, AMSTERDAM 1004, NETHERLANDS
关键词
1,1,1-Trichloroethane; Excretion; Metabolism; Tetrachloroethylene; Toxicokinetics; Trichloroethylene; Uptake; Volunteer exposure;
D O I
10.1007/BF00377785
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The relatively high and almost constant absorption/min of trichloroethylene (TRI) is explained by the relatively high partition coefficient between blood and air (.lambda.b/g = 15) combined with the rapid metabolism (75%). Tetrachloroethylene (PERC) has about the same .lambda.b/g as TRI but the metabolism is insignificant (2%); therefore, the amount taken up per min decreases in the course of exposure. The .lambda.b/g (5) for 1,1,1-trichloroethane (MC) is smaller and the metabolism is insignificant (3.5%); therefore, the capacity of the body to absorb MC is relatively small and the uptake per min decreases fast during exposure. Due to the lower .lambda.b/g the excretion of MC after exposure is much faster than that of PERC. As a result of the metabolism of TRI only a relatively small amount of TRI absorbed is excreted by the lungs after exposure. [This study is relevant to occupational toxicology.].
引用
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页码:311 / 317
页数:7
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