COLORIMETRIC DETERMINATION OF SOME N-1-SUBSTITUTED NITROIMIDAZOLES

被引：31

作者：

LAU, EPK

YAO, C

LEWIS, M

SENKOWSK.BZ

机构：

[1] Analytical Research Laboratory, Hoffmann-La Roche Inc, Nutley, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

1‐Methyl‐2‐isopropyl‐5‐nitroimidazole—determination; feed premix; Bratton‐Marshall reaction—analysis; Colorimetric analysis—spectrophotometer; Nitroimidazoles; N‐1‐substituted—analysis; Sulfanilamide reagent—diazotization; imidazole hydrolysis;

D O I：

10.1002/jps.2600580109

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A colorimetric method is presented for the determination of some N‐1‐substituted nitroimidazoles. The method utilizes diazotization of a sulfanilamide with the nitrite ions produced during the alkaline hydrolysis of the respective imidazole. Subsequent coupling is then carried out with Bratton‐Marshall reagent. The sensitivity of this method of analysis is approximately 0.1 mcg./ml. This procedure can be used for the determination of one of the N‐1‐substituted nitroimidazoles, 1‐methyl‐2‐isopropyl‐5‐nitroimidazole, in feed premixes containing multiple vitamins, and is herein presented. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：55 / &

共 9 条

[1]

BOLTZ DF, 1958, COLORIMETRIC DETERMI, P124

[2]

Bratton AC, 1939, J BIOL CHEM, V128, P537

[3]

CLEAR AJ, 1961, TREATISE ANALYTICA 2, V5, P275

[4] POLAROGRAPHIC DETERMINATION OF DIMETRIDAZOLE IN ANIMAL FEEDING STUFFS [J].

COOPER, PJ ;

HOODLESS, RA .

ANALYST, 1967, 92 (1097) :520-&

[5]

DAFTSIOS AC, 1964, J ASSOC OFF AGR CHEM, V47, P231

[6]

FEIGL F, 1966, SPOT TESTS ORGANIC A, P299

[7]

KOLTHOFF IM, 1961, TREATISE ANAL CHEM 2, V5, P275

[8]

LAU E, UNPUBLISHED DATA

[9]

TARAS MJ, 1958, COLORIMETRIC DETERMI, P124

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