INCREASED SERUM KININASE-I ACTIVITY IN PREGNANCY COMPLICATED BY PREECLAMPSIA

被引:7
作者
ITO, Y [1 ]
MIZUTANI, S [1 ]
NOMURA, S [1 ]
KURAUCHI, O [1 ]
KASUGAI, M [1 ]
NARITA, O [1 ]
TOMODA, Y [1 ]
机构
[1] NAGOYA UNIV,DEPT OBSTET & GYNECOL,65 TSURUMA CHO,SHOWA KU,NAGOYA,AICHI 466,JAPAN
关键词
bradykinin; feto-placental circulation; pre-eclampsia; Serum kininase I;
D O I
10.1055/s-2007-1004895
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Serum kininase I activity was measured in normal pregnancy and pre-eclampsia. The mean value in nonpregnant controls was 180±25 (SD) nmol/min/ml. Kininase I activity during normal pregnancy significantly increased after week 14, reaching the highest value (240±20 nmol/min/ml) at weeks 38 and 40. The kininase I activity in pregnancy complicated by severe pre-eclampsia was higher than that in normal pregnancy. The possible role played by elevated kininase I levels in pre-eclampsia was discussed.
引用
收藏
页码:252 / 255
页数:4
相关论文
共 20 条
[1]  
CUSHMAN DW, 1971, BIOCHEM PHARMACOL, V11, P585
[2]   RENIN, ALDOSTERONE, AND SERUM-CONVERTING ENZYME-ACTIVITY DURING NORMAL AND HYPERTENSIVE PREGNANCY [J].
DUX, S ;
YARON, A ;
CARMEL, A ;
ROSENFELD, JB .
GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1984, 17 (05) :252-257
[3]   CARBOXYPEPTIDASE IN BLOOD AND OTHER FLUIDS .3. ESTERASE ACTIVITY OF ENZYME [J].
ERDOS, EG ;
YANG, HYT ;
TAGUE, LL ;
MANNING, N .
BIOCHEMICAL PHARMACOLOGY, 1967, 16 (07) :1287-&
[4]   AN ENZYME IN HUMAN BLOOD PLASMA THAT INACTIVATES BRADYKININ AND KALLIDINS [J].
ERDOS, EG ;
SLOANE, EM .
BIOCHEMICAL PHARMACOLOGY, 1962, 11 (JUL) :585-+
[5]   CARBOXYPEPTIDASE IN BLOOD + OTHER FLUIDS .I. PROPERTIES DISTRIBUTION + PARTIAL PURIFICATION OF ENZYME [J].
ERDOS, EG ;
SLOANE, EM ;
WOHLER, IM .
BIOCHEMICAL PHARMACOLOGY, 1964, 13 (06) :893-&
[6]   PURIFICATION AND PROPERTIES OF MICROSOMAL CARBOXYPEPTIDASE-N (KININASE-I) IN HUMAN-PLACENTA [J].
ITO, Y ;
MIZUTANI, S ;
KURAUCHI, O ;
KASUGAI, M ;
NARITA, O ;
TOMODA, Y .
ENZYME, 1989, 42 (01) :8-14
[7]   ENZYMES IN PLACENTAL MICROVILLI - ANGIOTENSIN-I CONVERTING ENZYME, ANGIOTENSINASE-A, CARBOXYPEPTIDASE, AND NEUTRAL ENDOPEPTIDASE (ENKEPHALINASE) [J].
JOHNSON, AR ;
SKIDGEL, RA ;
GAFFORD, JT ;
ERDOS, EG .
PEPTIDES, 1984, 5 (04) :789-796
[8]  
KOHEIL A, 1978, BIOCHIM BIOPHYS ACTA, V524, P156, DOI 10.1016/0005-2744(78)90113-4
[9]   THE DEGRADATION OF BRADYKININ (BK) AND OF DES-ARG-9-BK IN PLASMA [J].
MARCEAU, F ;
GENDREAU, M ;
BARABE, J ;
STPIERRE, S ;
REGOLI, D .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1981, 59 (02) :131-138
[10]   KININS - POSSIBLE MEDIATORS OF NEONATAL CIRCULATORY CHANGES IN MAN [J].
MELMON, KL ;
CLINE, MJ ;
HUGHES, T ;
NIES, AS .
JOURNAL OF CLINICAL INVESTIGATION, 1968, 47 (06) :1295-&