INSULIN-LIKE GROWTH-FACTORS AND THECAL-GRANULOSA-CELL FUNCTION

被引：41

作者：

GEISTHOVEL, F ^{[1
]}

MORETTIROJAS, I ^{[1
]}

ROJAS, FJ ^{[1
]}

ASCH, RH ^{[1
]}

机构：

[1] UNIV FREIBURG,DEPT OBSTET & GYNECOL,DIV CLIN ENDOCRINOL,W-7800 FREIBURG,GERMANY

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 07期

关键词：

Folliculogenesis; IGF; Ovarian control; Reproductive disorders; Thecal-granulosa cell;

D O I：

10.1093/oxfordjournals.humrep.a137185

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Insulin-like growth factors (IGFs) belong to a family of low mol. wt, single chain plypeptides inducing growth promotion and insulin-like metabolism effects and regulating both cell replication and differentiation. Recent studies in laboratory animals suggest that IGFs play an important role as intraovarian regulators in several mammalian species. Tbe purpose of this article was to review current concepts of interactions between the IGFs and the thecal-granulosa-cell function. To provide a basic understanding of these interactions, we have first analysed data concerning biosynthesis, biochemical structure, pharmacokinetics, degradation, binding proteins and receptors for IGFs. Then we have discussed the specific interactions between IGFs and theca-granulosa-cell regulation, and analysed the significance of the relationship to the pathophysiology of some endocrine and reproductive disorders, including hyperandrogenism and female infertility. © 1990 Oxford University Press.

引用

页码：785 / 799

页数：15

共 122 条

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