ROLE OF PROTEIN-SYNTHESIS IN THE ACCUMULATION OF FERRITIN MESSENGER-RNA DURING EXPOSURE OF CELLS TO IRON

被引：18

作者：

MATTIA, E ^{[1
]}

DENBLAAUWEN, J ^{[1
]}

VANRENSWOUDE, J ^{[1
]}

机构：

[1] UNIV AMSTERDAM,EC SLATER INST BIOCHEM RES,PLANTAGE MUIDERGRACHT 12,1018 TV AMSTERDAM,NETHERLANDS

来源：

BIOCHEMICAL JOURNAL | 1990年 / 267卷 / 02期

关键词：

D O I：

10.1042/bj2670553

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The iron-induced biosynthesis of ferritin is regulated at the translational level via multiple mechanism. A prolonged exposure of cells to iron leads to a marked increase in ferritin mRNA levels caused by stabilization of the message. Here we show that this stabilization requires the synthesis de novo of an iron-inducible protein factor.

引用

页码：553 / 555

页数：3

共 16 条

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