MAPPING OF THE HUMAN VLA-ALPHA-4 GENE TO CHROMOSOME-2Q31-Q32

被引：13

作者：

FERNANDEZRUIZ, E

PARDOMANUELDEVILLENA, F

RUBIO, MA

CORBI, AL

DECORDOBA, SR

SANCHEZMADRID, F

机构：

[1] UNIV AUTONOMA MADRID,HOSP PRINCESA,SERV IMMUNOL,C-DIEGO DE LEON 62,E-28006 MADRID,SPAIN

[2] CTR INVEST BIOL,MADRID,SPAIN

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1992年 / 22卷 / 02期

关键词：

D O I：

10.1002/eji.1830220243

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The integrin VLA-4 (alpha-4:beta-1; CD49d/CD29) is involved in both cellular adhesion to extracellular matrix and cell-cell interactions. We have determined that the human gene coding for VLA-alpha-4 is located on the long arm of chromosome 2 by using fluorescence in situ hybridization. The VLA-alpha-4 gene has been more precisely mapped to the 2q31-q32 region after GTG banding (G-bands by trypsin using Giemsa). These data suggest that the VLA-4 gene belongs to the COL3A1-(ELN-FN)-COL6A3 linkage group and establishes a potential genetic relationship between the alpha-4 and alpha-v integrin subunits.

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页码：587 / 590

页数：4

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