BINDING OF [HISTAMINE-H-3 TO RECEPTOR-SITES IN RAT-BRAIN

被引：18

作者：

SINGH, VK ^{[1
]}

MCGEER, EG ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DIV NEUROL SCI,VANCOUVER V6T 1W5,BC,CANADA

来源：

EXPERIMENTAL NEUROLOGY | 1979年 / 66卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0014-4886(79)90092-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[3H]Histamine binds to crude synaptic membranes from rat brain with a dissociation constant of 0.683 μm. The hypothalamus shows the most binding among five other brain regions. Binding of [3H]histamine is not affected by noradrenaline, dopamine, or serotonin; however, it is inhibited more by H2 receptor than by H1 receptor agents, suggesting the prevalence of H2-histamine receptors in brain. © 1979.

引用

页码：413 / 418

页数：6

共 14 条

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