INHIBITION OF LANGERHANS CELL ATPASE AND CONTACT SENSITIZATION BY LANTHANIDES - ROLE OF T-SUPPRESSOR CELLS

被引:10
作者
GRUNER, S
DIEZEL, W
STRUNK, D
ECKERT, R
SIEMS, W
ANHALT, GJ
机构
[1] JOHNS HOPKINS UNIV,DEPT DERMATOL,600 N WOLFE ST,BALTIMORE,MD 21218
[2] UNIV ROSTOCK,DEPT DERMATOL,O-2500 ROSTOCK,GERMANY
[3] HUMBOLDT UNIV,DEPT DERMATOL,O-1086 BERLIN,GERMANY
[4] HUMBOLDT UNIV,DEPT BIOCHEM,O-1086 BERLIN,GERMANY
[5] HUMBOLDT UNIV,DEPT IMMUNOL,O-1086 BERLIN,GERMANY
关键词
D O I
10.1111/1523-1747.ep12481515
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Lanthanides are rare earths, elements 55 - 71 in the periodic table, that are of interest in biologic systems as isomorphic competitors for calcium binding sites. Lanthanides were tested for their inhibitory influence on the Ca++/Mg++-dependent ATPase of epidermal langerhans cells in vitro, and on the immunologic function of Langerhans cells in vivo. The trivalent ions of lanthanides, lanthanum, and cerium completely inhibited the ATPase staining of Langerhans cells in vitro. When mice were sensitized with dinitrofluorobenzene on skin sites pretreated with topical lanthanum chloride, and challenged on untreated ear skin, a markedly reduced contact hypersensitivity response was observed. This hyporesponsiveness was found to be antigen specific, and could be passively transferred to naive syngeneic animals recipients by CD4 - CD8 + spleen cells. These results suggest that inhibition of the epidermal Langerhans cell surface ATPase by application of topical lanthanum and the induction of antigen-specific immunologic tolerance may be related events.
引用
收藏
页码:478 / 482
页数:5
相关论文
共 21 条
[1]   ULTRAVIOLET-LIGHT DEPLETES SURFACE-MARKERS OF LANGERHANS CELLS [J].
ABERER, W ;
SCHULER, G ;
STINGL, G ;
HONIGSMANN, H ;
WOLFF, K .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1981, 76 (03) :202-210
[2]   RODENT EPIDERMAL LANGERHANS CELLS DEMONSTRATE GREATER HISTOCHEMICAL SPECIFICITY FOR ADP THAN FOR ATP AND AMP [J].
CHAKER, MB ;
THARP, MD ;
BERGSTRESSER, PR .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1984, 82 (05) :496-500
[3]   INHIBITION OF CUTANEOUS CONTACT HYPERSENSITIVITY BY CALCIUM-TRANSPORT INHIBITORS LANTHANUM AND DILTIAZEM [J].
DIEZEL, W ;
GRUNER, S ;
DIAZ, LA ;
ANHALT, GJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1989, 93 (03) :322-326
[4]   ANALYSIS OF THE MECHANISM OF UNRESPONSIVENESS PRODUCED BY HAPTENS PAINTED ON SKIN EXPOSED TO LOW-DOSE ULTRAVIOLET-RADIATION [J].
ELMETS, CA ;
BERGSTRESSER, PR ;
TIGELAAR, RE ;
WOOD, PJ ;
STREILEIN, JW .
JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (03) :781-794
[5]   INTERESTING AND USEFUL BIOCHEMICAL-PROPERTIES OF LANTHANIDES [J].
EVANS, CH .
TRENDS IN BIOCHEMICAL SCIENCES, 1983, 8 (12) :445-449
[6]   EPIDERMAL I-J-BEARING CELLS ARE RESPONSIBLE FOR TRANSFERABLE SUPPRESSOR-CELL GENERATION AFTER IMMUNIZATION OF MICE WITH ULTRAVIOLET RADIATION-TREATED EPIDERMAL-CELLS [J].
GRANSTEIN, RD .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1985, 84 (03) :206-209
[7]  
GRANSTEIN RD, 1987, J IMMUNOL, V138, P4055
[8]   HUMAN EPIDERMAL LANGERHANS CELLS INTERNALIZE BY RECEPTOR-MEDIATED ENDOCYTOSIS-T6 (CD1 NA1/34) SURFACE-ANTIGEN - BIRBECK GRANULES ARE INVOLVED IN THE INTRACELLULAR TRAFFIC OF THE T6 ANTIGEN [J].
HANAU, D ;
FABRE, M ;
SCHMITT, DA ;
STAMPF, JL ;
GARAUD, JC ;
BIEBER, T ;
GROSSHANS, E ;
BENEZRA, C ;
CAZENAVE, JP .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 89 (02) :172-177
[9]  
IACOBELLI D, 1985, PHOTODERMATOLOGY, V2, P132
[10]  
KRIPKE ML, 1985, J INVEST DERMATOL S, V85, P62