IDENTIFICATION OF A CONSISTENT PATTERN OF MUTATIONS IN NEUROVIRULENT VARIANTS DERIVED FROM THE SABIN VACCINE STRAIN OF POLIOVIRUS TYPE-2

被引：28

作者：

EQUESTRE, M

GENOVESE, D

CAVALIERI, F

FIORE, L

SANTORO, R

BERCOFF, RP

机构：

[1] UNIV ROME,INST VIROL,I-00100 ROME,ITALY

[2] IST SUPER SANITA,VIROL LAB,I-00161 ROME,ITALY

[3] CTR RIC SCLAVO SPA,SIENA,ITALY

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 05期

关键词：

D O I：

10.1128/JVI.65.5.2707-2710.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants of poliovirus type 2.

引用

页码：2707 / 2710

页数：4

共 33 条

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