BANS - A DISCUSSION OF THE PROBLEM

被引：16

作者：

BERNENGO, MG

REALI, UM

DOVEIL, GC

CAPPELLO, N

LISA, F

MORETTI, S

机构：

[1] Dermatological Clinic, University of Turin, Turin, 1-10126

[2] Department of Plastic and Reconstructive Surgery, Dermatological Clinic II, University of Florence

[3] Department of Genetics, Biology and Chemical Chemistry, University of Turin

[4] Dermatological Clinic II, University of Florence, Florence

来源：

MELANOMA RESEARCH | 1992年 / 2卷 / 03期

关键词：

BANS REGION; CUTANEOUS MELANOMA STAGE-I; PROGNOSIS; SURVIVAL; RECURRENCE; MULTIVARIATE ANALYSIS;

D O I：

10.1097/00008390-199209000-00003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The significance of the BANS location (upper Back, posterior Arm, Neck and Scalp) as a prognostic factor in patients with stage I melanoma is controversial. A meta-analysis performed by Weinstock et al. on their own and five comparable studies corroborated the hypothesis that this location is influential in the prognosis of intermediate thickness (0.76-1.69 mm) melanomas. Our study investigated the relationship between BANS subsites, thickness and prognosis in 1,082 stage I melanoma patients from two major Italian centres, Turin and Florence. A BANS primary was observed in 212 (19.5%) patients: recurrences occurred in 85 of them (40.1%) vs 309/870 non-BANS patients (35.5%). Overall survival probabilities were significantly shorter (p < 0.01) in the BANS group (69.1% vs 76.7% at 5 years; 59% vs 68.5% at 10 years). The prognostic value of the BANS location was confirmed by a multivariate analysis using the Cox proportional hazards model. Stratification of BANS and non-BANS groups by thickness clusters showed a significant difference in both survival (p < 0.001) and disease-free interval (p < 0.05) in the 3.01-4.00 mm thickness subset, due to the greater incidence of distant and visceral metastases. In the 0.76-1.69 mm thickness range the significance was p = 0.06.

引用

页码：157 / 162

页数：6

共 15 条

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