ATHYMIC EXPERIMENTAL-ANIMALS IN PHARMACOIMMUNOLOGICAL RESEARCH

被引：4

作者：

JUUL, P

CHRISTENSEN, HB

HOUGEN, HP

SVENDSEN, O

THYGESEN, P

RYGAARD, J

机构：

[1] KOMMUNE HOSP COPENHAGEN,BARTHOLIN INST,DK-1399 COPENHAGEN K,DENMARK

[2] ROYAL DANISH SCH PHARM,DEPT BIOL SCI,DK-2100 COPENHAGEN,DENMARK

[3] SCANTOX,LILLE SKENSVED,DENMARK

来源：

TOXICOLOGY LETTERS | 1992年 / 64-5卷

关键词：

NUDE MICE; NUDE RATS; STREPTOZOTOCIN; DIABETES-MELLITUS; GUANETHIDINE; SYMPATHECTOMY; TOXICOLOGY;

D O I：

10.1016/0378-4274(92)90176-K

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

Immunodeficient animals - the nude mouse and the nude rat - allow studies of drug action and possible side effects without interference from the immune system. Comparative investigations in athymic and euthymic animals allowed us to elucidate the role of T-lymphocytes in the pathogenesis of streptozotocin-induced diabetes mellitus in mice, and the importance of NK-cells as effectors in guanethidine-induced sympathectomy in the rat. It is suggested that immunodeficient animals should be included in toxicological studies of xenobiotics.

引用

页码：85 / 92

页数：8

共 17 条

[1]

BOVEN E, 1992, NUDE MOUSE ONCOLOGY

[2]

BUSCHARD K, 1978, ACTA PATH MICRO IM C, V86, P23

[3]

BUSCHARD K, 1977, ACTA PATH MICRO IM C, V85, P469

[4]

BUSCHARD K, 1978, ACTA PATH MICRO IM C, V86, P277

[5]

ATHYMIC NUDE MUTATION IN RAT [J].

FESTING, MFW ;

MAY, D ;

CONNORS, TA ;

LOVELL, D ;

SPARROW, S .

NATURE, 1978, 274 (5669) :365-366

[6]

FOGH J, 1982, NUDE MOUSE EXPT CLIN, V1

[7]

HOUGEN HP, 1992, IN PRESS INT J IMMUN

[8]

HOUGEN HP, 1991, APMIS S21, V99

[9]

JENSENHOLM J, 1967, ACTA PHARMACOL TOX, VS 25, P74

[10]

GUANETHIDINE-INDUCED SYMPATHECTOMY IN THE NUDE RAT [J].

JUUL, A ;

JUUL, P ;

CHRISTENSEN, HB .

PHARMACOLOGY & TOXICOLOGY, 1989, 64 (01) :20-22

← 1 2 →