ESSENTIAL FATTY-ACID DEFICIENCY LOWERS THE ACTIVITY OF THE ACETYLATED LOW-DENSITY-LIPOPROTEIN RECEPTOR OF RAT PERITONEAL-MACROPHAGES

被引：5

作者：

GAVINO, GR ^{[1
]}

LEVY, E ^{[1
]}

GAVINO, VC ^{[1
]}

机构：

[1] UNIV MONTREAL,FAC MED,DEPT NUTR,MONTREAL H3C 3J7,QUEBEC,CANADA

来源：

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 1992年 / 70卷 / 3-4期

关键词：

MACROPHAGE; ACETYL LOW-DENSITY LIPOPROTEIN; ACETYL LOW-DENSITY LIPOPROTEIN RECEPTOR; CHOLESTEROL; ESSENTIAL FATTY ACID DEFICIENCY;

D O I：

10.1139/o92-033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We compared phospholipid fatty acid composition, cholesterol ester accumulation, and receptor-mediated binding, internalization, and degradation of acetylated low-density lipoprotein (acetyl-LDL) in cultured peritoneal macrophages from rats fed an essential fatty acid deficient or control diet. The deficient diet increased the 5,8,11-eicosatrienoic acid and decreased the omega-6 fatty acid content of macrophage phospholipid relative to control. The deficient diet did not affect macrophage uptake of [1-C-14]oleate; however, it lowered the accumulation of intracellular labelled cholesteroyl oleate to 66% of the control. This effect was attributed to a diminution of the specific binding of acetyl-LDL, and not to acetyl-LDL internalization nor to degradation. The results demonstrate the sensitivity of the acetyl-LDL receptor to changes in its membrane environment, brought about through dietary means.

引用

页码：224 / 227

页数：4

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